Mots-C (40mg)
MOTS-c (40mg) | The Mitochondrial "Exercise Mimetic" Peptide
MOTS-c (Mitochondrial Open Reading Frame of the 12S rRNA-c) is a groundbreaking 16-amino acid peptide encoded within the mitochondrial genome rather than the cell nucleus. Known in research circles as an "exercise mimetic," MOTS-c functions as a systemic metabolic signal that mimics the beneficial effects of physical exertion by shifting the body’s metabolic flux toward fatty acid oxidation and enhanced glucose utilization.
Mechanism of Action
MOTS-c acts as a bridge between mitochondrial health and nuclear gene expression:
AMPK Activation: It triggers the AMPK pathway (the "metabolic master switch"), which stimulates glucose uptake in skeletal muscle without requiring increased insulin.
Mito-Nuclear Communication: Under metabolic stress, MOTS-c translocates to the nucleus to regulate stress-adaptation genes, improving cellular resilience.
Folate Cycle Inhibition: It promotes the accumulation of AICAR, a potent metabolic regulator that further enhances energy production and fat burning.
Fitness & Performance Research Benefits
In longitudinal and acute research models, MOTS-c has shown profound implications for physical optimization:
Endurance & Aerobic Capacity: Research indicates MOTS-c can significantly increase oxygen consumption and treadmill running time, even in subjects not currently undergoing active training.
Fat Oxidation & Weight Management: MOTS-c prevents diet-induced obesity by promoting the breakdown of lipids and preventing the accumulation of visceral fat.
Improved Insulin Sensitivity: By mimicking the metabolic signals of exercise, it helps restore glucose homeostasis and combats insulin resistance.
Skeletal Muscle Integrity: MOTS-c is studied for its ability to prevent age-related muscle wasting (sarcopenia) and improve the regenerative capacity of muscle fibers.
Metabolic Flexibility: It enhances the body’s ability to efficiently switch between burning carbohydrates and stored fats as fuel sources.
Research Disclaimer: This product is intended for laboratory research purposes only. It is not approved for human consumption. MOTS-c is currently on the WADA Prohibited List (S2. Hormone and Metabolic Modulators) for competitive athletes.
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