S-23 (1080mg/30ml) | The "Male Contraceptive" SARM

S-23 is a high-affinity, non-steroidal Selective Androgen Receptor Modulator (SARM) derived from the compound C-6. It is widely regarded as one of the most powerful SARMs in existence, often compared to the strongest traditional anabolic agents. In clinical research, S-23 was specifically investigated for its potential as a male hormonal contraceptive due to its ability to induce temporary infertility by suppressing spermatogenesis. In the research community, however, it is primarily studied for its profound effects on muscle hardness and fat loss.

Mechanism of Action

S-23 functions as an extremely potent agonist for androgen receptors with a unique biological profile:

• Near-Total Receptor Saturation: It binds to androgen receptors with an exceptionally high affinity ($K_i$ of $0.52 nM$), which is significantly stronger than most other SARMs.

• Spermatogenesis Suppression: It acts on the pituitary gland to suppress follicle-stimulating hormone (FSH) and luteinizing hormone (LH), which are essential for sperm production.

• Tissue Selectivity: While it is highly anabolic in muscle and bone, it was designed to be less stimulatory to the prostate than conventional testosterone.

• Non-Aromatizing: S-23 does not convert to estrogen, allowing researchers to study its effects without the interference of water retention.

Fitness & Research Benefits

In advanced body recomposition and strength research, S-23 is used to study the limits of "dry" muscle accumulation:

• Unmatched Muscle Hardness: Research subjects typically demonstrate a level of muscle graininess and "dryness" that is rarely seen with other non-steroidal compounds.

• Aggressive Fat Oxidation: It is highly effective in research models focused on reducing visceral and subcutaneous fat while simultaneously increasing lean tissue.

• Significant Strength Increase: Due to its high binding affinity, S-23 is a primary subject for studying rapid improvements in raw power and explosive strength.

• Enhanced Vascularity: Researchers often observe a significant increase in visible vascularity and a "chiseled" appearance in test models.

• Preservation in Deep Deficits: It is studied for its ability to prevent muscle wasting even during periods of extreme caloric restriction, making it a "top-tier" cutting research agent.

Technical Specifications

• Chemical Name: (S)-3-(4-chloro-3-fluorophenoxy)-N-(4-cyano-3-(trifluoromethyl)phenyl)-2-hydroxy-2-methylpropanamide

• Storage: Store at room temperature (15-30°C). Keep in a cool, dark place. S-23 is highly stable but should be protected from direct UV light.