KPV (Lys-Pro-Val) | 10mg Anti-Inflammatory Research Peptide

KPV is a naturally occurring tripeptide composed of the amino acids Lysine-Proline-Valine. It represents the C-terminal three-amino-acid sequence of alpha-melanocyte-stimulating hormone (α-MSH), a signaling peptide known for its role in regulating inflammatory responses. KPV has attracted significant interest in peptide research because it appears to retain many of the anti-inflammatory properties of α-MSH while functioning as a much smaller peptide fragment.

Research has primarily focused on KPV’s potential effects on inflammatory signaling, intestinal inflammation, immune regulation, and antimicrobial activity. Most available evidence comes from laboratory and animal studies, and KPV has not been established as an approved treatment for these conditions in humans.

Mechanism of Action

KPV is being investigated through several cellular pathways associated with inflammation and immune signaling:

NF-κB Inhibition: Laboratory research has demonstrated that KPV can inhibit activation of NF-κB, a major transcription factor responsible for regulating numerous inflammatory genes. Reduced NF-κB signaling has been associated with lower expression of inflammatory mediators in experimental models.

MAP Kinase Regulation: KPV has also been shown experimentally to influence MAP kinase signaling pathways, including ERK, JNK, and p38, which participate in cellular stress and inflammatory responses.

PepT1-Mediated Cellular Uptake: Research in intestinal epithelial and immune cells suggests that KPV can be transported into cells through the peptide transporter PepT1. This pathway has been investigated extensively in experimental models of intestinal inflammation.

Cytokine Modulation: In cell and animal studies, KPV exposure has been associated with reductions in several pro-inflammatory signaling molecules and inflammatory cytokine expression. These findings are one reason KPV is being studied in models involving excessive inflammatory activity.

Inflammation, Gut & Recovery Research

KPV is of particular interest in research involving inflammatory balance and tissue environments:

Intestinal Inflammation: Some of the most established KPV research involves experimental models of colitis. In mouse studies, KPV reduced histological signs of intestinal inflammation and decreased expression of pro-inflammatory cytokines.

Inflammatory Response Regulation: Because KPV interacts with pathways such as NF-κB and MAP kinase signaling, researchers are examining its potential role in controlling excessive inflammatory responses without broadly suppressing normal cellular function.

Tissue Recovery Research: Inflammation is a fundamental component of tissue repair and recovery. KPV is therefore being investigated in broader research involving inflammatory balance, cellular stress, and recovery environments. Evidence for specific performance or injury-recovery benefits in humans, however, remains limited.

Antimicrobial Research: Early laboratory studies involving α-MSH-derived peptides found that KPV demonstrated antimicrobial activity against organisms including Staphylococcus aureus and Candida albicans, creating additional interest in its role within innate-defense research.

Technical Specifications

Full Name: Lysyl-Prolyl-ValineAbbreviation: KPVSequence: Lys-Pro-ValSequence Code: K-P-VMolecular Weight: Approximately 342.43 g/molMolecular Formula: C16H30N4O4

Storage: For long-term laboratory storage, lyophilized peptide material is commonly maintained frozen and protected from moisture and direct light. Follow the specific storage and handling specifications supplied with the research material.

Research Disclaimer: This product is intended strictly for laboratory research purposes only. It is not intended for human or veterinary use, diagnosis, treatment, prevention, or cure of any disease. KPV has not been established as an FDA-approved drug for human use. All research must be conducted in accordance with applicable institutional, local, state, and federal regulations.